Hydrochloric Acid → 1-(2-Bromo-4-chlorophenyl)ethanol

HRID 405234

反応式

HRID 405234 の反応式
[BH4-].[Na+].C1COCC1.[Br:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[C:16](=[O:18])[CH3:17].Cl>CO>[Br:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[CH:16]([OH:18])[CH3:17]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 4311764Sodium borohydrideHCID 47126441-(2-Bromo-4-chlorophenyl)ethanone

生成物 1

HCID 574450731-(2-Bromo-4-chlorophenyl)ethanol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Solid NaBH4 (354 mg, 9.4 mmol) was added to a 0° C., THF (5 mL) and MeOH (15 mL) solution of 1-(2-bromo-4-chlorophenyl)ethanone (1.8 g, 7.8 mmol). After 30 min 2N aqueous HCl was slowly added, and the resulting mixture was extracted with EtOAc. The combined organic extracts were dried (Na2SO4), concentrated, and purified via column chromatography to yield the title compound.

後処理

  1. extractionthe resulting mixture was extracted with EtOAc
  2. dry with materialThe combined organic extracts were dried (Na2SO4)
  3. concentrationconcentrated
  4. custompurified via column chromatography

出典と根拠

ORDレコード
ord-de0ade1835f8404786d55c3e197ec22f
出典データセット
uspto-grants-2014_06
特許番号
US08748624B2

関連ノート

読み込み中…