Acetonitrile → 5-bromo-N-cyclobutylpyrimidin-2-amine
反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.[CH:9]1([NH2:13])[CH2:12][CH2:11][CH2:10]1.CCN(C(C)C)C(C)C.C(#N)C>CCOC(C)=O>[Br:1][C:2]1[CH:3]=[N:4][C:5]([NH:13][CH:9]2[CH2:12][CH2:11][CH2:10]2)=[N:6][CH:7]=1参加物
6
反応条件
- 温度
- 50 °C
実験手順
In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine, 1.15 mL (13.4 mmol) cyclobutylamin and 2.70 mL (15.5 mmol) DIPEA are added to 12 mL ACN. The reaction mixture is stirred at 50° C. over night, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo.
後処理
- washwashed with water (2×)
- dry with materialphase is dried with MgSO4
- customthe solvent is removed in vacuo
出典と根拠
- ORDレコード
- ord-2a3a2743c1e9484fb35ba6c301538793
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08530460B2
反応ノート
読み込み中…