Acetonitrile → 5-bromo-N-cyclobutylpyrimidin-2-amine

HRID 40562

反応式

HRID 40562 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.[CH:9]1([NH2:13])[CH2:12][CH2:11][CH2:10]1.CCN(C(C)C)C(C)C.C(#N)C>CCOC(C)=O>[Br:1][C:2]1[CH:3]=[N:4][C:5]([NH:13][CH:9]2[CH2:12][CH2:11][CH2:10]2)=[N:6][CH:7]=1

参加物

6

反応物 4

HCID 6342AcetonitrileHCID 75645CyclobutylamineHCID 81531DiisopropylethylamineHCID 6066655-Bromo-2-chloropyrimidine

生成物 1

HCID 451586875-bromo-N-cyclobutylpyrimidin-2-amine

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
50 °C

実験手順

In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine, 1.15 mL (13.4 mmol) cyclobutylamin and 2.70 mL (15.5 mmol) DIPEA are added to 12 mL ACN. The reaction mixture is stirred at 50° C. over night, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo.

後処理

  1. washwashed with water (2×)
  2. dry with materialphase is dried with MgSO4
  3. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-2a3a2743c1e9484fb35ba6c301538793
出典データセット
uspto-grants-2013_09
特許番号
US08530460B2

関連ノート

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