Chlorotrimethylsilane → Methyl 2,2,4-Trimethyl-3-silyloxypent-3-enecarboxylate

HRID 411887

反応式

HRID 411887 の反応式
[CH3:1][C:2]1([CH3:10])[C:5](=O)[C:4]([CH3:8])([CH3:7])[C:3]1=[O:9].[CH3:11][O-:12].[Na+].C[Si:15](Cl)(C)C.[O:19]1[CH2:23]CCC1>>[CH3:10][C:2]([CH3:1])([C:3]([O:9][SiH3:15])=[C:4]([CH3:7])[CH3:8])[CH2:5][C:11]([O:19][CH3:23])=[O:12]

参加物

5

反応物 4

HCID 6397ChlorotrimethylsilaneHCID 8028TetrahydrofuranHCID 136172,2,4,4-Tetramethyl-1,3-cyclobutanedioneHCID 10942334Sodium Methoxide

生成物 1

HCID 123759875Methyl 2,2,4-Trimethyl-3-silyloxypent-3-enecarboxylate

実験手順

84 g (0.6 mol) of 2,2,4,4-tetramethylcyclobutane-1,3-dione and 32.4 g (0.6 mol) of sodium methylate were mixed together in 320 ml of tetrahydrofuran. 65.1 g (0.6 mol) of trimethylsilyl chloride were added dropwise and the mixture was stirred. The reaction mixture was then concentrated and the residue was taken up with diethyl ether. The solid was filtered off with suction and the mother liquor was concentrated. Yield: 135 g (89%).

後処理

  1. concentrationThe reaction mixture was then concentrated
  2. filtrationThe solid was filtered off with suction
  3. concentrationthe mother liquor was concentrated

出典と根拠

ORDレコード
ord-018233e2db2a44b78cd771c96c80a5be
出典データセット
uspto-grants-2003_05
特許番号
US06559343B1

関連ノート

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