Trimethylamine → (-)-Carnitine

HRID 413513

反応式

HRID 413513 の反応式
Cl[CH2:2][C@H:3]([OH:10])[CH2:4][C:5]([O:7]CC)=[O:6].[CH3:11][N:12]([CH3:14])[CH3:13]>O>[OH:10][C@H:3]([CH2:4][C:5](=[O:6])[O-:7])[CH2:2][N+:12]([CH3:14])([CH3:13])[CH3:11]

参加物

4

反応物 2

HCID 1146TrimethylamineHCID 27344454-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-

生成物 1

HCID 10917(-)-Carnitine収率 75%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

400 g of crude ethyl (+) (R)-4-chloro-3-hydroxybutyrate, prepared according to Example 8, and 1 l of 45% trimethylamine in H2O are placed in a 2-liter reactor. The reaction mixture is heated to 80° C. and kept at this temperature for 15 h. After cooling and removing the excess of trimethylamine under nitrogen flow, the aqueous solution is extracted with 1.9 l of methylene chloride and analyzed with HPLC. L-carnitine is obtained with 75% yield.

後処理

  1. customare placed in a 2-liter reactor
  2. temperatureAfter cooling
  3. customremoving the excess of trimethylamine under nitrogen flow
  4. extractionthe aqueous solution is extracted with 1.9 l of methylene chloride

出典と根拠

ORDレコード
ord-c8f4026d15844e13a4a08c4f23aeab51
出典データセット
uspto-grants-2003_05
特許番号
US06566552B2

関連ノート

読み込み中…