Water → 3-(4-Trifluoromethylphenylthio)propanal

HRID 414030

反応式

HRID 414030 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([SH:9])=[CH:5][CH:4]=1.[CH:12]([CH:14]=[CH2:15])=[O:13].O>C1COCC1.C(N(CC)CC)C>[F:11][C:2]([F:1])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([S:9][CH2:15][CH2:14][CH:12]=[O:13])=[CH:7][CH:8]=1

参加物

6

反応物 3

HCID 962WaterHCID 7847AcroleinHCID 1366534-(Trifluoromethyl)thiophenol

生成物 1

HCID 143479823-(4-Trifluoromethylphenylthio)propanal収率 99.6%

試薬・触媒・溶媒 2

HCID 8471Triethylamine触媒HCID 8028Tetrahydrofuran溶媒

実験手順

Ten grams of 4-trifluoromethylthiophenol was dissolved in 15 ml of THF, and after adding 4.0 g of 95% acrolein under ice-cooling, 0.1 g of triethylamine was added while thoroughly stirring the reaction solution. After stirring for 1.5 hours under ice-cooling, the reaction solution was poured into water and extracted with ether. The ether layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to obtain 13.1 g of 3-(4-trifluoromethylphenylthio)propionaldehyde.

後処理

  1. temperaturecooling
  2. stirringAfter stirring for 1.5 hours under ice-
  3. temperaturecooling
  4. extractionextracted with ether
  5. washThe ether layer was washed with water
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-8fffb9f5120448a293a9012ddff4bfe1
出典データセット
uspto-grants-1988_12
特許番号
US04789396

関連ノート

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