4-Chlorophenyl cyclopropyl ketone → (4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime

HRID 423023

反応式

HRID 423023 の反応式
Cl.[O:2]([NH2:4])[CH3:3].[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH:14]2[CH2:16][CH2:15]2)=O)=[CH:8][CH:7]=1>N1C=CC=CC=1>[CH3:3][O:2][N:4]=[C:12]([C:9]1[CH:8]=[CH:7][C:6]([Cl:5])=[CH:11][CH:10]=1)[CH:14]1[CH2:16][CH2:15]1

参加物

4

反応物 2

HCID 811484-Chlorophenyl cyclopropyl ketoneHCID 521874O-Methylhydroxylamine hydrochloride

生成物 1

HCID 73696106(4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime収率 87.4%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
25 °C

実験手順

Methoxylamine hydrochloride (2.004 g) was added to (4-chlorophenyl)(cyclopropyl)methanone (2.71 g) in pyridine (60 mL) at 25° C. The resulting solution was stirred at 25° C. for 24 hours. The pyridine was removed in vacuo, and the residual solid extracted with ether. Filtration and evaporation of the solvent gave the crude (4-chlorophenyl)(cyclopropyl)methanone O-methyl oxime (2.75 g, 87%) as a yellow oil. This material was used directly in the next step without further purification.

後処理

  1. customThe pyridine was removed in vacuo
  2. extractionthe residual solid extracted with ether
  3. filtrationFiltration and evaporation of the solvent

出典と根拠

ORDレコード
ord-820c7f43ceda4a6a8685cd0aafeb45e2
出典データセット
uspto-grants-2012_01
特許番号
US08101623B2

関連ノート

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