Methyl Vanillate → Methyl 4-hydroxy-3-iodo-5-methoxybenzoate

HRID 423259ノート

反応式

HRID 423259 の反応式
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([O:11][CH3:12])[CH:5]=1.[I:14]N1C(=O)CCC1=O>O1CCCC1>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:5]=[C:6]([O:11][CH3:12])[C:7]([OH:10])=[C:8]([I:14])[CH:9]=1

参加物

4

反応物 2

HCID 19844Methyl VanillateHCID 120273N-Iodosuccinimide

生成物 1

HCID 53426739Methyl 4-hydroxy-3-iodo-5-methoxybenzoate収率 113.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 4-hydroxy-3-methoxybenzoic acid methyl ester (5.0 g) in tetrahydrofuran (20 mL) was added N-iodosuccinimide (6.17 g) at 0° C., and the mixture was stirred for 1 hour. The precipitated solid was filtered, washed with water, and dried to give the title compound (9.60 g).

後処理

  1. filtrationThe precipitated solid was filtered
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-91f5d4f170584cc5abefa9ba12bcba63
出典データセット
uspto-grants-2012_01
特許番号
US08101774B2

反応ノート

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