Sodium Carbonate → HCID 178471833、化合物

HRID 423336

反応式

HRID 423336 の反応式
[C:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])#[N:2].[NH2:19][OH:20].Cl.C([O-])([O-])=O.[Na+].[Na+]>CCO>[OH:20][NH:19][C:1](=[NH:2])[C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH:5]=[CH:6][N:7]2[CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochloride2 回HCID 59318406Ethyl 3-(4-cyano-1H-indol-1-yl)propanoate

生成物 1

HCID 178471833HCID 178471833、化合物収率 103.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

Ethyl 3-(4-cyano-1H-indol-1-yl)propanoate (D54) (3.44 g), NH2OH.HCl (1.97 g) and Na2CO3 (5.96 g) were dissolved in EtOH (75 ml). This mixture was heated at 50° C. overnight. A further portion of NH2OH.HCl (985 mg) was added and the mixture stirred at 70° C. overnight. The reaction mixture was then filtered and evaporated to give the title compound (4.06 g). MS (ES): C14H17N3O3 requires 275; found 276 (MH+)

後処理

  1. filtrationThe reaction mixture was then filtered
  2. customevaporated

出典と根拠

ORDレコード
ord-dd893dce617e4ced8e0a263297264b48
出典データセット
uspto-grants-2012_01
特許番号
US08101775B2

関連ノート

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