Hydantoin → 5-(4-Methyl-4-nitropentylidene)hydantoin

HRID 433002ノート

反応式

HRID 433002 の反応式
[CH3:1][C:2]([N+:8]([O-:10])=[O:9])([CH3:7])[CH2:3][CH2:4][CH:5]=O.[NH:11]1[CH2:17][C:15](=[O:16])[NH:14][C:12]1=[O:13].C(=O)([O-])[O-].[Na+].[Na+]>C(#N)C>[CH3:1][C:2]([N+:8]([O-:10])=[O:9])([CH3:7])[CH2:3][CH2:4][CH:5]=[C:17]1[NH:11][C:12](=[O:13])[NH:14][C:15]1=[O:16]

参加物

5

反応物 3

HCID 10006HydantoinHCID 10340Sodium CarbonateHCID 122640094-Methyl-4-nitrovaleraldehyde

生成物 1

HCID 695837495-(4-Methyl-4-nitropentylidene)hydantoin収率 50%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Oily 4-methyl-4-nitropentanal (4.0 g, 28 mmol), hydantoin (4.0 g, 40 mmol) and sodium carbonate (2.8 g, 20 mmol) were added to 50% aqueous acetonitrile (200 ml) and the mixture was refluxed with stirring for 3 days. The reaction mixture was concentrated and extracted three times with ethyl acetate. The organic layer was concentrated to dryness to give 5-(4-methyl-4-nitropentylidene)hydantoin (3.15 g, 13.9 mmol, yield 50.0%).

後処理

  1. temperaturethe mixture was refluxed
  2. concentrationThe reaction mixture was concentrated
  3. extractionextracted three times with ethyl acetate
  4. concentrationThe organic layer was concentrated to dryness

出典と根拠

ORDレコード
ord-042b77606d6445ecb95b0e439cb23c3a
出典データセット
uspto-grants-2003_12
特許番号
US06664412B2

反応ノート

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