Pyridine → Tert-butyl 1-chloroethyl carbonate

HRID 4425

反応式

HRID 4425 の反応式
[C:1]([OH:5])([CH3:4])([CH3:3])[CH3:2].Cl[C:7]([O:9][CH:10]([Cl:12])[CH3:11])=[O:8].N1C=CC=CC=1>ClCCl>[C:7](=[O:8])([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])[O:9][CH:10]([Cl:12])[CH3:11]

参加物

5

反応物 3

HCID 1049PyridineHCID 6386tert-ButanolHCID 5213051-Chloroethyl chloroformate

生成物 1

HCID 13557091Tert-butyl 1-chloroethyl carbonate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In a reactor cooled to +5° C., there are introduced 600 ml of dicloromethane, 43.7 g (0.59 mole) of tert-butanol and 94.7 g (0.66 mole) of α-chloroethyl chloroformate. 57 g (0.72 mole) of pyridine are then added dropwise and with stirring while the temperature is maintained at between 10° and 20° C. The mixture is stirred for 4 hours at room temperature.

後処理

  1. temperatureIn a reactor cooled to +5° C.
  2. temperatureis maintained at between 10° and 20° C
  3. stirringThe mixture is stirred for 4 hours at room temperature

出典と根拠

ORDレコード
ord-eb26a125028f488199001eac7c1803da
出典データセット
uspto-grants-1988_02
特許番号
US04725680

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