Water → 2,4-dichloro-N-(1-methyltetrazol-5-yl)benzamide

HRID 448848

反応式

HRID 448848 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:12][N:13]1[C:17]([NH2:18])=[N:16][N:15]=[N:14]1.N1C=CC=CC=1.O>C(#N)C>[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([NH:18][C:17]1[N:13]([CH3:12])[N:14]=[N:15][N:16]=1)=[O:5]

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 666452,4-Dichlorobenzoyl chlorideHCID 1384921-methyl-1H-tetrazol-5-amine

生成物 1

HCID 666065252,4-dichloro-N-(1-methyltetrazol-5-yl)benzamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

In a microwave oven, 209 mg (1.0 mmol) of 2,4-dichlorobenzoyl chloride, 198 mg (2.0 mmol) of 1-methyl-5-aminotetrazole and 237 mg (3 mmol) of pyridine in 3 ml of acetonitrile are stirred at 130° C. for 45 min. Water is then added, and the product is filtered off with suction and washed with ether. Yield 80 mg (30%).

後処理

  1. filtrationthe product is filtered off with suction
  2. washwashed with ether

出典と根拠

ORDレコード
ord-1e077ed3306f4005a44ab0d8c8cd395b
出典データセット
uspto-grants-2013_07
特許番号
US08481749B2

関連ノート

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