Pyridine → Methyl acetyl(p-bromobenzoyl)acetate

HRID 45590

反応式

HRID 45590 の反応式
[CH3:1][O:2][C:3](=[O:9])[CH:4]=[C:5](NC)[CH3:6].N1C=CC=CC=1.[Br:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1.C1C[O:29]CC1>>[CH3:1][O:2][C:3](=[O:9])[CH:4]([C:21](=[O:22])[C:20]1[CH:24]=[CH:25][C:17]([Br:16])=[CH:18][CH:19]=1)[C:5](=[O:29])[CH3:6]

参加物

5

反応物 4

HCID 1049PyridineHCID 8028Tetrahydrofuran2 回HCID 685154-Bromobenzoyl chlorideHCID 2734182Methyl 3-(methylamino)but-2-enoate

生成物 1

HCID 603116Methyl acetyl(p-bromobenzoyl)acetate

反応条件

温度
0 °C

実験手順

To 3-methylamino-but-2-enoic acid methyl ester (5.0 g, 39.1 mmol) in THF (100 mL) was added pyridine (3.7 mL, 47 mmol). The mixture was cooled to 0° C., and 4-bromobenzoyl chloride (8.55 g, 39.1 mmol) in THF (30 mL) was added dropwise over 2 minutes. The reaction was warmed to room temperature over 1 hour and stirred overnight. Aqueous workup provided the title compound.

後処理

  1. temperatureThe reaction was warmed to room temperature over 1 hour

出典と根拠

ORDレコード
ord-34df59fc39704324b6849d543dc6d57b
出典データセット
uspto-grants-2013_09
特許番号
US08541587B2

関連ノート

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