Methyl iodide → 4-Bromo-2-(methoxymethyl)thiophene

HRID 456528

反応式

HRID 456528 の反応式
[H-].[Na+].[CH3:3]I.[Br:5][C:6]1[CH:7]=[C:8]([CH2:11][OH:12])[S:9][CH:10]=1>O1CCCC1>[Br:5][C:6]1[CH:7]=[C:8]([CH2:11][O:12][CH3:3])[S:9][CH:10]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 2795484(4-Bromo-2-thienyl)methanol

生成物 1

HCID 150183124-Bromo-2-(methoxymethyl)thiophene

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Add sodium hydride (737 mg, 29.23 mmol, 1.10 equivalents, 95%) to a solution containing methyl iodide (1.65 mL, 26.57 mmol, 1.00 equivalents) and (4-bromo-thiophen-2-yl)-methanol (5.13 g, 26.57 mmol, 1.00 equivalents) in tetrahydrofuran (dry, 25 mL). Stir the resulting mixture at room temperature overnight and evaporate. Partition the residue between water (100 mL) and dichloromethane (100 mL). Extract the aqueous layer with dichloromethane (100 mL), combine the organic layers, dry over magnesium sulfate, filter and evaporate to yield the desired product as a yellow oil.

後処理

  1. customevaporate
  2. customPartition the residue between water (100 mL) and dichloromethane (100 mL)
  3. extractionExtract the aqueous layer with dichloromethane (100 mL)
  4. dry with materialdry over magnesium sulfate
  5. filtrationfilter
  6. customevaporate

出典と根拠

ORDレコード
ord-ac324890fddb41bea7ead4ba5dc52f23
出典データセット
uspto-grants-2007_03
特許番号
US07186724B2

関連ノート

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