5-Chlorosalicylic Acid → 5-Chloro-2-hydroxybenzoyl chloride

HRID 457938

反応式

HRID 457938 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:14])=O>CCCCCCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([Cl:14])=[O:8]

参加物

4

反応物 2

HCID 94475-Chlorosalicylic AcidHCID 24386Thionyl Chloride

生成物 1

HCID 128632335-Chloro-2-hydroxybenzoyl chloride収率 99.3%

試薬・触媒・溶媒 1

HCID 8900Heptane溶媒

反応条件

温度
60 °C

実験手順

A solution of 5-chloro-2-hydroxy-benzoic acid (20.0 g, 116 mmol) in heptane (232 mL, 0.5 M) was treated with thionyl chloride (25.4 mL, 348 mmol) and heated to 60° C. for 6 h. After cooling to room temperature, the solution was concentrated under reduced pressure to give 5-chloro-2-hydroxy-benzoyl chloride as a thick yellow oil (22 g) which was used without further purification.

後処理

  1. temperatureAfter cooling to room temperature
  2. concentrationthe solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-a2eab2155d4c4b518cbf2bcd1b497a70
出典データセット
uspto-grants-2007_03
特許番号
US07189749B2

関連ノート

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