Chloroacetonitrile → HCID 20225324、化合物

HRID 463674

反応式

HRID 463674 の反応式
[CH2:1]([NH:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2].Cl[CH2:12][C:13]#[N:14].C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1>[CH2:1]([N:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:12][C:13]#[N:14])[CH3:2]

参加物

5

反応物 3

HCID 7856ChloroacetonitrileHCID 10340Sodium CarbonateHCID 480381-Heptanamine, N-ethyl-

生成物 1

HCID 20225324HCID 20225324、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
125 °C

実験手順

Combine 7.95 g (0.055 moles) ethyl(heptyl)amine, 3.5 ml (0.055 moles) chloroacetonitrile, 5.8 g (0.055 moles) sodium carbonate and 25 ml toluene in a sealed pressure tube. Heat to 125° C. for 18 hrs. Follow the progress of the reaction by thin layer chromatography on silica gel (CH3CN+MeOH+NH4OH, 85+10+5). At the completion of the reaction, filter the reaction mixture and evaporate the solvents to provide the title compound.

後処理

  1. customthe progress of the reaction by thin layer chromatography on silica gel (CH3CN+MeOH+NH4OH, 85+10+5)
  2. customAt the completion of the reaction
  3. filtrationfilter the reaction mixture
  4. customevaporate the solvents

出典と根拠

ORDレコード
ord-848d384f4a9e4071b0ce402d368bbeaf
出典データセット
uspto-grants-1985_10
特許番号
US04544654

関連ノート

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