Chloroacetonitrile → 2-[Ethyl(heptyl)amino]acetonitrile
反応式
[CH2:1]([NH:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:2].Cl[CH2:12][C:13]#[N:14].C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1>[CH2:1]([N:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:12][C:13]#[N:14])[CH3:2]参加物
5
反応条件
- 温度
- 125 °C
実験手順
Combine 7.95 g (0.055 moles) ethyl(heptyl)amine, 3.5 ml (0.055 moles) chloroacetonitrile, 5.8 g (0.055 moles) sodium carbonate and 25 ml toluene in a sealed pressure tube. Heat to 125° C. for 18 hrs. Follow the progress of the reaction by thin layer chromatography on silica gel (CH3CN+MeOH+NH4OH, 85+10+5). At the completion of the reaction, filter the reaction mixture and evaporate the solvents to provide the title compound.
後処理
- customthe progress of the reaction by thin layer chromatography on silica gel (CH3CN+MeOH+NH4OH, 85+10+5)
- customAt the completion of the reaction
- filtrationfilter the reaction mixture
- customevaporate the solvents
出典と根拠
- ORDレコード
- ord-848d384f4a9e4071b0ce402d368bbeaf
- 出典データセット
- uspto-grants-1985_10
- 特許番号
- US04544654
反応ノート
読み込み中…