Pyridine → HCID 20263705、化合物

HRID 464038ノート

反応式

HRID 464038 の反応式
[F:1][C:2]([F:9])([F:8])[C:3]1[NH:7][N:6]=[N:5][N:4]=1.[C:10](Cl)(=[O:26])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25].N1C=CC=CC=1>C(#N)C>[C:10]([N:4]1[C:3]([C:2]([F:9])([F:8])[F:1])=[N:7][N:6]=[N:5]1)(=[O:26])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

参加物

5

反応物 3

HCID 1049PyridineHCID 8206Palmitoyl chlorideHCID 178506305HCID 178506305、化合物

生成物 1

HCID 20263705HCID 20263705、化合物収率 43.7%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
5 °C

実験手順

6.9 g of 5-trifluoromethyl-1,2,3,4-tetrazole and 13.7 g of palmitoyl chloride were dissolved in 100 ml of acetonitrile while cooling with ice and to the solution was added dropwise 4.5 ml of pyridine over a period of about 10 minutes. After the completion of the dropwise addition, the mixture was stirred at about 5° C. for 30 minutes and then at room temperature for 1 hour, and to the mixture was added dropwise about 100 ml of ice water. The crystals thus-deposited were collected by filtration to obtain 8.2 g of 1-hexadecanoyl-5-trifluoromethyl-1,2,3,4 -tetrazole. A melting point was 66° to 69° C.

後処理

  1. temperaturewhile cooling with ice and to the solution
  2. additionAfter the completion of the dropwise addition
  3. waitat room temperature for 1 hour
  4. filtrationThe crystals thus-deposited were collected by filtration

出典と根拠

ORDレコード
ord-8c5e73afbf9a4faea9e53a36551afd1a
出典データセット
uspto-grants-1985_10
特許番号
US04546075

反応ノート

読み込み中…