1,3-Dibromopropane → 1-(3-Bromopropoxy)-4-fluorobenzene
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Br:15][CH2:16][CH2:17][CH2:18]Br.C(COC)OC>C(Cl)Cl>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:18][CH2:17][CH2:16][Br:15])=[CH:4][CH:3]=1参加物
6
実験手順
A mixture of 11.2 g (0.1 mol) of 4-fluorophenol, 16.5 g (0.12 mol) of pulverized potassium carbonate, 20.2 g (0.1 mol) of 1,3-dibromopropane and 100 ml of anhydrous dimethoxyethane was refluxed under nitrogen for 6 hours and then cooled. The mixture was diluted with methylene chloride and washed with water. The resultant organic product solution was dried over Na2SO4 and evaporated in vacuo. The residue was chromatographed on silica gel using cyclohexane elution to give pure product.
後処理
- temperaturewas refluxed under nitrogen for 6 hours
- temperaturecooled
- washwashed with water
- dry with materialThe resultant organic product solution was dried over Na2SO4
- customevaporated in vacuo
- customThe residue was chromatographed on silica gel
- washcyclohexane elution
- customto give pure product
出典と根拠
- ORDレコード
- ord-60b5ca190a014fdba9710dfad12d80e0
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05159097
反応ノート
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