Trifluoroacetic acid → 5,7-Dichloro-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

HRID 47369

反応式

HRID 47369 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].C=C[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.F[C:26](F)(F)[C:27](O)=O>C(#N)C>[CH2:26]([O:15][C:13]([CH:12]1[CH2:10][CH:11]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:3]2[C:4](=[CH:6][C:7]([Cl:9])=[CH:8][C:2]=2[Cl:1])[NH:5]1)=[O:14])[CH3:27]

参加物

6

反応物 4

HCID 6422Trifluoroacetic acidHCID 7501StyreneHCID 122813,5-DichloroanilineHCID 35932772-Ketobutyrate

生成物 1

HCID 102693095,7-Dichloro-4-phenyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Compound 14 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol styrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.

出典と根拠

ORDレコード
ord-e8a931743b8149fd99a983cfe51a6d2b
出典データセット
uspto-grants-2004_03
特許番号
US06699877B2

関連ノート

読み込み中…