Trifluoroacetic acid → 5,7-dichloro-4-(2,4-dimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

HRID 47376ノート

反応式

HRID 47376 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].[CH3:17][C:18]1[CH:25]=[C:24]([CH3:26])[CH:23]=[CH:22][C:19]=1C=C.FC(F)(F)C(O)=O.[OH-].[Na+]>C(#N)C.C(O)C>[Cl:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:4]2[C:3]=1[CH:11]([C:19]1[CH:22]=[CH:23][C:24]([CH3:26])=[CH:25][C:18]=1[CH3:17])[CH2:10][CH:12]([C:13]([OH:15])=[O:14])[NH:5]2

参加物

8

反応物 5

HCID 6422Trifluoroacetic acidHCID 122813,5-DichloroanilineHCID 14798Sodium HydroxideHCID 166942,4-DimethylstyreneHCID 35932772-Ketobutyrate

生成物 1

HCID 99463775,7-dichloro-4-(2,4-dimethylphenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic Acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6342Acetonitrile溶媒

実験手順

Compound 22 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 2,4-dimethylstyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile. Subsequent saponification was carried out using 1.0 ml of sodium hydroxide solution (6N water) in 20.0 ml of ethanol.

出典と根拠

ORDレコード
ord-a0336ceea30a42ed8d5a3bc52c698fd4
出典データセット
uspto-grants-2004_03
特許番号
US06699877B2

反応ノート

読み込み中…