Potassium Acetate → 6-Bromo-1H-indazole

HRID 473782

反応式

HRID 473782 の反応式
F[B-](F)(F)F.[Br:6][C:7]1[CH:8]=[CH:9][C:10]([CH3:15])=[C:11]([N+:13]#[N:14])[CH:12]=1.C([O-])(=O)C.[K+]>C(Cl)(Cl)Cl.C1OCCOCCOCCOCCOCCOC1>[Br:6][C:7]1[CH:12]=[C:11]2[C:10]([CH:15]=[N:14][NH:13]2)=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 517044Potassium AcetateHCID 805030315-Bromo-2-methylbenzenediazonium tetrafluoroborate

生成物 1

HCID 178424716-Bromo-1H-indazole収率 86.7%

試薬・触媒・溶媒 2

HCID 2855718-Crown-6触媒HCID 6212Chloroform溶媒

実験手順

5-Bromo-2-methylphenyldiazonium tetrafluoroborate (1.50 g) was added to a mixture of potassium acetate (1.0 g) and 18-crown-6 (70 mg) in chloroform (50 mL) at room temperature in portions and then the reaction was stirred for 2 h. The resulting mixture was filtered and washed with chloroform. The filtrate was concentrated, and the residue was dissolved in diethyl ether, which was then washed with water, brine, dried, and the solvent was removed to give the product 6-bromoindazole (0.9 g). The product was used in the next step without further purification.

後処理

  1. filtrationThe resulting mixture was filtered
  2. washwashed with chloroform
  3. concentrationThe filtrate was concentrated
  4. dissolutionthe residue was dissolved in diethyl ether
  5. washwhich was then washed with water, brine
  6. customdried
  7. customthe solvent was removed

出典と根拠

ORDレコード
ord-66804a95cd6e4a919da44c3a3ec0d8a7
出典データセット
uspto-grants-2014_01
特許番号
US08637497B2

関連ノート

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