Potassium Acetate → 6-Bromo-1H-indazole
反応式
F[B-](F)(F)F.[Br:6][C:7]1[CH:8]=[CH:9][C:10]([CH3:15])=[C:11]([N+:13]#[N:14])[CH:12]=1.C([O-])(=O)C.[K+]>C(Cl)(Cl)Cl.C1OCCOCCOCCOCCOCCOC1>[Br:6][C:7]1[CH:12]=[C:11]2[C:10]([CH:15]=[N:14][NH:13]2)=[CH:9][CH:8]=1参加物
5
実験手順
5-Bromo-2-methylphenyldiazonium tetrafluoroborate (1.50 g) was added to a mixture of potassium acetate (1.0 g) and 18-crown-6 (70 mg) in chloroform (50 mL) at room temperature in portions and then the reaction was stirred for 2 h. The resulting mixture was filtered and washed with chloroform. The filtrate was concentrated, and the residue was dissolved in diethyl ether, which was then washed with water, brine, dried, and the solvent was removed to give the product 6-bromoindazole (0.9 g). The product was used in the next step without further purification.
後処理
- filtrationThe resulting mixture was filtered
- washwashed with chloroform
- concentrationThe filtrate was concentrated
- dissolutionthe residue was dissolved in diethyl ether
- washwhich was then washed with water, brine
- customdried
- customthe solvent was removed
出典と根拠
- ORDレコード
- ord-66804a95cd6e4a919da44c3a3ec0d8a7
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08637497B2
反応ノート
読み込み中…