Sodium hydride → 1-(Trifluoromethyl)-3-(4-vinylphenoxy)benzene
反応式
[H-].[Na+].[F:3][C:4]([F:21])([F:20])[C:5]1[CH:6]=[C:7]([CH:17]=[CH:18][CH:19]=1)[O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1.[I-].[CH3:23][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>C1COCC1>[F:3][C:4]([F:21])([F:20])[C:5]1[CH:19]=[CH:18][CH:17]=[C:7]([O:8][C:9]2[CH:16]=[CH:15][C:12]([CH:13]=[CH2:23])=[CH:11][CH:10]=2)[CH:6]=1参加物
5
実験手順
NaH (23.66 g, 592 mmol) was added to the solution of 4-(3-(trifluoromethyl)phenoxy)-benzaldehyde (25 g, 94 mmol) and methyltriphenylphosphonium iodide (36.2 g, 101 mmol) in THF (180 mL) at 0° C. The reaction mixture was stirred at room temperature overnight. Purification via a flash column chromatography then afforded the title compound as a colorless oil (24.4 g, 98% yield).