Chloroacetamide → Ethyl 2,5-dioxo-3-pyrrolidinecarboxylate

HRID 483104

反応式

HRID 483104 の反応式
[C:1]([O:9]CC)(=O)[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[H-].[Na+].Cl[CH2:15][C:16]([NH2:18])=[O:17]>CN(C)C=O>[CH2:6]([O:5][C:3]([CH:2]1[CH2:15][C:16](=[O:17])[NH:18][C:1]1=[O:9])=[O:4])[CH3:7]

参加物

5

反応物 3

HCID 6580ChloroacetamideHCID 7761Diethyl MalonateHCID 24758Sodium hydride

生成物 1

HCID 23635561Ethyl 2,5-dioxo-3-pyrrolidinecarboxylate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of diethyl malonate (6.1 ml) in N,N-dimethylformamide (30 ml) are added 60% sodium hydride (1.6 g) at 0° C. and, after 8 minutes, chloroacetamide (1.87 g). After stirring at room temperature for 3.5 hours, the mixture in neutralized with acetic acid and extracted with ethyl acetate. The extract is washed with water and concentrated to give 2,5-dioxopyrrolidine-3-carboxylic acid ethyl ester. Oil.

後処理

  1. extractionthe mixture in neutralized with acetic acid and extracted with ethyl acetate
  2. washThe extract is washed with water
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-a315d93cc0df448580a90e1858c3b76d
出典データセット
uspto-grants-1986_03
特許番号
US04578378

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