Pyridine → Methyl 4-chloromethyl-2-nitrobenzoate
反応式
O[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1.S(Cl)([Cl:18])=O.N1C=CC=CC=1.CCOCC>O1CCCC1>[Cl:18][CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1参加物
6
実験手順
A mixture of methyl 4-hydroxymethyl-2-nitrobenzoate (1.49 g), thionyl chloride (1.08 g), dry pyridine (0.1 g), dry ether (70 ml) and dry tetrahydrofuran (20 ml) was stirred overnight. The reaction mixture was washed in turn with 1N hydrochloric acid and sat. sodium bicarbonate solution, dried over magnesium sulfate and evaporated to give methyl 4-chloromethyl-2-nitrobenzoate (1.60 g).
後処理
- washThe reaction mixture was washed in turn with 1N hydrochloric acid and sat. sodium bicarbonate solution
- dry with materialdried over magnesium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-2d1966d1c4134d5eaa2b15dd0f211dc7
- 出典データセット
- uspto-grants-1994_03
- 特許番号
- US05296487
反応ノート
読み込み中…