1-Chloro-2-(trifluoromethyl)benzene → HCID 532426、化合物

HRID 487749

反応式

HRID 487749 の反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17](O)=[CH:16][CH:15]=1.C1(P(C2C=CC=CC=2)CCCCP(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:51](=[O:54])([O-])[O-:52].[Na+].[Na+].[C]=O>[Pd](Cl)Cl>[F:9][C:8]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:51]([O:52][C:17]1[CH:18]=[CH:19][C:14]([O:13][CH3:12])=[CH:15][CH:16]=1)=[O:54]

参加物

7

反応物 5

HCID 69211-Chloro-2-(trifluoromethyl)benzeneHCID 90154-MethoxyphenolHCID 10340Sodium CarbonateHCID 821241,4-Bis(diphenylphosphino)butaneHCID 178418416HCID 178418416、化合物2 回

生成物 1

HCID 532426HCID 532426、化合物

試薬・触媒・溶媒 1

HCID 24290Palladium Chloride触媒

実験手順

In an autoclave made of a metal were placed 45.13 g of ortho-chlorobenzotrifluoride, 6.2 g of para-methoxyphenol, 88.5 mg of palladium chloride, 213 mg of 1,4-bisdiphenylphosphinobutane and 5.3 g of sodium carbonate. The air in the autoclave was replaced with carbon monoxide introduced thereinto in several times, after which carbon monoxide was further introduced to adjust its pressure therein to 30 kg/cm2. The internal temperature was adjusted to 190° C. on a salt bath and the reaction was carried out thereon with stirring for 5 hours.

後処理

  1. additionintroduced
  2. customThe internal temperature was adjusted to 190° C. on a salt bath

出典と根拠

ORDレコード
ord-d55c1ac288e24512823a757050b66de0
出典データセット
uspto-grants-1994_03
特許番号
US05296601

関連ノート

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