Trifluoroacetic acid → 4-fluoro-N,N-dimethyl-D-prolinamide trifluoroacetate

HRID 490134

反応式

HRID 490134 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][N:9]([CH3:25])[C:10]([C@H:12]1[CH2:16][CH:15]([F:17])[CH2:14][N:13]1C(OC(C)(C)C)=O)=[O:11]>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:17][CH:15]1[CH2:14][NH:13][C@@H:12]([C:10]([N:9]([CH3:25])[CH3:8])=[O:11])[CH2:16]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 69064202tert-butyl(2R)-2-[(dimethylamino)carbonyl]-4-fluoropyrrolidine-1-carboxylate

生成物 1

HCID 690618314-fluoro-N,N-dimethyl-D-prolinamide trifluoroacetate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

10 mL of trifluoroacetic acid was added under ice cooling to a 30 mL chloroform solution of 2.09 g of the compound obtained in step 6-2, after which the reaction mixture was stirred for 2 hours at room temperature. The reaction mixture was then concentrated under reduced pressure, which gave 3.42 g of residue (pale yellow oily substance). This compound was used in the following reaction without being purified.

後処理

  1. concentrationThe reaction mixture was then concentrated under reduced pressure, which

出典と根拠

ORDレコード
ord-cd9a3c58831a439fa2eb5c0b3085fd58
出典データセット
uspto-grants-2009_05
特許番号
US07528124B2

関連ノート

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