Ammonium formate → HCID 57675753、化合物

HRID 491044ノート

反応式

HRID 491044 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:23]3[C:18](=[CH:19][C:20]([O:24][CH3:25])=[CH:21][CH:22]=3)[CH:17]=[C:16]2[CH2:26][O:27][CH3:28])=[CH:11][CH:10]=1)C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.O1CCCC1.[Pd]>[CH3:25][O:24][C:20]1[CH:19]=[C:18]2[C:23](=[CH:22][CH:21]=1)[N:15]([C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=1)[C:16]([CH2:26][O:27][CH3:28])=[CH:17]2

参加物

6

反応物 2

HCID 2723923Ammonium formateHCID 57675751HCID 57675751、化合物

生成物 1

HCID 57675753HCID 57675753、化合物

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

1-(4-Benzyloxyphenyl)-5-methoxy-2-methoxymethyl-1H-indole (0.16 g, 0.43 mmol) was dissolved in methanol (3 mL) and tetrahydrofuran (1 mL). Palladium on carbon (0.32 g, 10% wet) and ammonium formate (0.14 g, 2.14 mmol) were added, and the reaction was stirred at reflux for 2 hours. The mixture was cooled to room temperature and filtered through a pad of Celite. The filtrate was concentrated, and the crude material taken on without purification. LC-MS (C17H17NO3 calc'd 283) m/z 284 (M+H).

後処理

  1. temperatureat reflux for 2 hours
  2. filtrationfiltered through a pad of Celite
  3. concentrationThe filtrate was concentrated
  4. customthe crude material taken on without purification

出典と根拠

ORDレコード
ord-d1721458dcc54198ab694ece37afea89
出典データセット
uspto-grants-2009_05
特許番号
US07528262B2

反応ノート

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