Hydrochloric Acid → HCID 178418666、化合物
反応式
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.C(N(CC)CC)C.[N-:25]=[N+:26]=[N-:27].[Na+].Cl>CN(C=O)C.O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]2[NH:27][N:26]=[N:25][N:14]=2)=[CH:15][CH:16]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
7
実験手順
A mixture of 285 g of the nitrile, 262.5 g triethylamine hydrochloride and 124 g of sodium azide in 1.5 L of DMF under nitrogen was stirred under reflux for 18 hrs. The reaction mixture was cooled to room temperature, poured into 4 L of cold water and acidified with 3N HCl. The resulting white solid was collected, washed with water and dried at 60° C. in vacuo for 48 hrs to give 337 g of 5-(4-benzyloxyphenyl)tetrazole.
後処理
- temperatureunder reflux for 18 hrs
- customThe resulting white solid was collected
- washwashed with water
- customdried at 60° C. in vacuo for 48 hrs
出典と根拠
- ORDレコード
- ord-da4ba2e333534753ac71b51a2ea124e5
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05242924
反応ノート
読み込み中…