Hydrochloric Acid → Ethyl (3-chlorophenyl)carbamate
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].Cl[C:10]([O:12][CH2:13][CH3:14])=[O:11].Cl>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:10](=[O:11])[O:12][CH2:13][CH3:14])[CH:6]=[CH:7][CH:8]=1参加物
5
実験手順
3-Chloroaniline (2.510 g) was dissolved in pyridine (20 ml), and to the solution was added dropwise ethyl chloroformate (2.257 ml) under ice-cooling. After the mixture was stirred for 1 hour, 1N hydrochloric acid was added and the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, and then saturated brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title compound (3.9287 g, quantitative yield).
後処理
- temperaturecooling
- extractionthe mixture was extracted with ethyl acetate
- washThe organic layer was washed with 1N hydrochloric acid
- dry with materialsaturated brine, dried over anhydrous magnesium sulfate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-692c75bd73dd43c4b0495b1a0b0416bd
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06939887B2
反応ノート
読み込み中…