Acetonitrile → 3-[3-(6-Methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

HRID 498234ノート

反応式

HRID 498234 の反応式
CO[C:3](=[O:17])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[N:12][C:13]([CH3:16])=[CH:14][CH:15]=2)[CH:5]=1.[C:18]([C:21]1C=C(B(O)O)C=CC=1)([OH:20])=[O:19].ClC1N=N[C:34]([CH3:37])=[CH:35]C=1.O=S(Cl)Cl.[C:42](#N)C>C([O-])([O-])=O.[Na+].[Na+]>[C:34]([O:20][C:18](=[O:19])[CH2:21][C:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[N:12][C:13]([CH3:16])=[CH:14][CH:15]=2)[CH:5]=1)=[O:17])([CH3:35])([CH3:37])[CH3:42]

参加物

7

反応物 5

HCID 6342AcetonitrileHCID 24386Thionyl ChlorideHCID 2272543-Chloro-6-methylpyridazineHCID 27339573-Carboxyphenylboronic acidHCID 69489500Methyl 3-(6-methylpyridazin-3-yl)benzoate

生成物 1

HCID 694864463-[3-(6-Methyl-pyridazin-3-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

試薬・触媒・溶媒 1

HCID 10340Sodium Carbonate溶媒

実験手順

The title compound was prepared from 3-(6-methyl-pyridazin-3-yl)-benzoic acid methyl ester [prepared by the following procedure: A mixture of 3-carboxyphenylboronic acid (2.24 g, 13.5 mmol) and 3-chloro-6-methylpyridazine (1.79 g, 13.5 mmol) in acetonitrile (67 mL) and 0.4M Na2CO3-solution (67 mL) was degassed and Pd(Ph3P)4 (0.78 g, 5 mol %) was added. The reaction mixture was refluxed for 16 h, evaporated to dryness (cf. Synlett 2000, 829). The residue was suspended in MeOH (200 mL) and SOCl2 (4.9 mL, 67.5 mmol) was added dropwise at 23° C. and the reaction mixture was refluxed for 16 h. Evaporated to dryness, taken up in EtOAc, washed with sat. NaHCO3-solution and brine, dried over Na2SO4. Removal of the solvent in vacuum left a brown oil, which was purified by silica gel column chromatography with cyclohexane/EtOAc.] (2.57 g, 11.26 mmol) by treatment with lithium tert-butyl acetate according to general procedure K (method b). Obtained as a light yellow solid (2.68 g).

後処理

  1. customprepared by the following procedure
  2. customwas degassed
  3. additionPd(Ph3P)4 (0.78 g, 5 mol %) was added
  4. temperatureThe reaction mixture was refluxed for 16 h
  5. customevaporated to dryness (cf. Synlett 2000, 829)
  6. temperaturethe reaction mixture was refluxed for 16 h
  7. customEvaporated to dryness
  8. washwashed with sat. NaHCO3-solution and brine
  9. dry with materialdried over Na2SO4
  10. customRemoval of the solvent in vacuum
  11. waitleft a brown oil, which
  12. customwas purified by silica gel column chromatography with cyclohexane/EtOAc

出典と根拠

ORDレコード
ord-20a8303ad28b4b439f681ef4e684d1c6
出典データセット
uspto-grants-2005_09
特許番号
US06949542B2

反応ノート

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