Water → 2-Bromo-4-thienyl-methoxyethyl methacrylate

HRID 5050

反応式

HRID 5050 の反応式
[Br:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][O:8][CH2:9]CO)[CH:6]=1.N1C=CC=C[CH:13]=1.C(#N)C.[C:21](Cl)(=[O:25])[C:22]([CH3:24])=[CH2:23].[OH2:27]>C(OCC)(=O)C>[C:21]([O:25][CH2:13][CH:7]([C:5]1[CH:6]=[C:2]([Br:1])[S:3][CH:4]=1)[O:8][CH3:9])(=[O:27])[C:22]([CH3:24])=[CH2:23]

参加物

7

反応物 5

HCID 962WaterHCID 1049PyridineHCID 6342AcetonitrileHCID 13528Methacryloyl chlorideHCID 197977502-Bromo-4-2-hydroxyethoxymethylthiophene

生成物 1

HCID 570171242-Bromo-4-thienyl-methoxyethyl methacrylate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

While stirring a mixture of 0.1 mol of 2-bromo-4-2-hydroxyethoxymethylthiophene, 0.1 mol of pyridine, and 100 ml of acetonitrile at a temperature of lower than 10° C., 0.1 mol of methacryloyl chloride was added dropwise to the mixture over a period of 30 minutes. After stirring the mixture for one hour, 200 ml of ethyl acetate and 200 ml of water were added to the mixture. The ethyl acetate layer was extracted, concentrated, and purified by column chromatography to provide 22.1 g of 2-bromo-4-thienyl-methoxyethyl methacrylate (5-A).

後処理

  1. stirringAfter stirring the mixture for one hour
  2. extractionThe ethyl acetate layer was extracted
  3. concentrationconcentrated
  4. custompurified by column chromatography

出典と根拠

ORDレコード
ord-65ea4057d75b4366aba54ef2265871f0
出典データセット
uspto-grants-1993_09
特許番号
US05243004

関連ノート

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