Guanidine Hydrochloride → 2-Aminopyrimidine-5-carbaldehyde
反応式
C[NH+]([CH2:4][C:5]([CH2:10]N(C)C)=[CH:6][NH+](C)C)C.Cl.[NH2:15][C:16]([NH2:18])=[NH:17].[OH-:19].[Na+]>C(#N)C.O>[NH2:17][C:16]1[N:18]=[CH:6][C:5]([CH:10]=[O:19])=[CH:4][N:15]=1参加物
6
反応条件
- 温度
- 25 °C
実験手順
Vinamidinium salt (68, 158 g, 413 mmol) and guanidine hydrochloride (69, 63.3 g, 455 mmol) were dissolved in 527 mL of acetonitrile and cooled on an ice/water bath. Sodium hydroxide (66.1 mL, 50% w/w, 827 mmol) was added dropwise, keeping the temperature below 25° C. The reaction was allowed to warm to 25° C. and stirred for 4 hours, then diluted with water and filtered, stripped from ethanol/heptane, then triturated with heptane. The resulting solid was dried under vacuum to provide the desired compound (70, 37 g, 301 mmol, 72.7% yield).
後処理
- temperaturecooled on an ice/water bath
- customthe temperature below 25° C
- filtrationfiltered
- customtriturated with heptane
- customThe resulting solid was dried under vacuum
出典と根拠
- ORDレコード
- ord-39a7bd8d7676421aba74e057bdfad832
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09096593B2
反応ノート
読み込み中…