Lithium Hydroxide → 3-[1-(4-Tert-butyl-phenyl)-piperidin-4-yl]-propionic acid lithium salt

HRID 511184ノート

反応式

HRID 511184 の反応式
C[O:2][C:3](=[O:22])[CH2:4][CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1.[OH-].[Li+:24].O1CCCC1>O.C(#N)C>[Li+:24].[C:18]([C:15]1[CH:14]=[CH:13][C:12]([N:9]2[CH2:10][CH2:11][CH:6]([CH2:5][CH2:4][C:3]([O-:22])=[O:2])[CH2:7][CH2:8]2)=[CH:17][CH:16]=1)([CH3:21])([CH3:19])[CH3:20]

参加物

6

反応物 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 585763793-[1-(4-Tert-butyl-phenyl)-piperidin-4-yl]-propionic acid methyl ester

生成物 1

HCID 585759763-[1-(4-Tert-butyl-phenyl)-piperidin-4-yl]-propionic acid lithium salt

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6342Acetonitrile溶媒

実験手順

To 3-[1-(4-tert-butyl-phenyl)-piperidin-4-yl]-propionic acid methyl ester (295 mg; 0.97 mmol, prepared in accordance with Example 145) is added lithium hydroxide (72 mg; 3.00 mmol) dissolved in water (6.5 mL). After dilution with tetrahydrofuran (10 mL) the reaction mixture is stirred for 2-4 hours. The mixture is then diluted with acetonitrile until a precipitate is formed. The solid is collected by filtration and dried under high vacuum to deliver the desired product (468 mg) which is used in the next step without further purification.

後処理

  1. customis formed
  2. filtrationThe solid is collected by filtration
  3. customdried under high vacuum
  4. customis used in the next step without further purification

出典と根拠

ORDレコード
ord-755d8b18423240c894b081756c8a8013
出典データセット
uspto-grants-2015_08
特許番号
US09096524B2

反応ノート

読み込み中…