反応式
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([NH:13][CH3:14])=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].Br.Br[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=1.[F:30][C:31]1[CH:39]=[CH:38][C:34]([C:35](O)=[O:36])=[CH:33][CH:32]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C>CN(C=O)C.C1COCC1>[F:30][C:31]1[CH:39]=[CH:38][C:34]([C:35]([NH:12][C:10]2[S:11][C:7]3[C:6]([N:13]([CH3:14])[CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:36])=[CH:33][CH:32]=1参加物
9
反応物 6
HCID 99734-Fluorobenzoic Acid
HCID 11430Potassium Carbonate
HCID 81531Diisopropylethylamine
HCID 27347202-(Bromomethyl)pyridine hydrobromide
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 227369784-methoxy-N7-methyl-benzothiazole-2,7-diamine生成物 1
試薬・触媒・溶媒 2
実験手順
From 4-methoxy-N7-methyl-benzothiazole-2,7-diamine with potassium carbonate and 2-(bromomethyl)pyridine hydrobromide in DMF, then treatment with 4-fluoro-benzoic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 423 (M+H+, 100).
出典と根拠
- ORDレコード
- ord-c5ed0a147f8c4cc5b2b6aa8bb1ace50b
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06713499B2
関連ノート
読み込み中…