Acetyl chloride → HCID 22736982、化合物

HRID 51883

反応式

HRID 51883 の反応式
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([NH:13][CH2:14][CH2:15][O:16][CH3:17])=[CH:5][CH:4]=1.[C:18](Cl)(=[O:20])[CH3:19].[Br:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][N:31]=1)[C:26](O)=[O:27].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CN1CCOCC1>ClCCl.C1COCC1.N1C=CC=CC=1>[C:18]([N:13]([CH2:14][CH2:15][O:16][CH3:17])[C:6]1[C:7]2[S:11][C:10]([NH:12][C:26](=[O:27])[C:25]3[CH:29]=[CH:30][N:31]=[C:23]([Br:22])[CH:24]=3)=[N:9][C:8]=2[C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)(=[O:20])[CH3:19]

参加物

9

反応物 5

HCID 6367Acetyl chlorideHCID 79724-MethylmorpholineHCID 2227012-Bromoisonicotinic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 227369804-methoxy-N7-(2-methoxy-ethyl)-benzothiazole-2,7-diamine

生成物 1

HCID 22736982HCID 22736982、化合物

試薬・触媒・溶媒 3

HCID 1049Pyridine溶媒HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

From 4-methoxy-N7-(2-methoxy-ethyl)-benzothiazole-2,7-diamine with pyridine and acetyl chloride in dichloromethane and THF, then treatment with 2-bromo-isonicotinic acid, HATU and N-methylmopholine in THF. ES-MS m/e (%): 481 (M{81Br}+H+, 100), 479 (M{79Br}+H+, 99).

出典と根拠

ORDレコード
ord-81866feb449a4ab48a3efda43d9b29dc
出典データセット
uspto-grants-2004_03
特許番号
US06713499B2

関連ノート

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