反応式
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11]C=2C(N)=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].IC[C:22]([N:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1)=O.IC.[F:32][C:33]1[CH:41]=[CH:40][C:36]([C:37]([OH:39])=O)=[CH:35][CH:34]=1.CN(C(ON1N=N[C:52]2[CH:53]=[CH:54][CH:55]=[N:56][C:51]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C>CN(C=O)C.C1COCC1>[F:32][C:33]1[CH:34]=[CH:35][C:36]([C:37]([NH:12][C:10]2[S:11][C:28]3[C:29]([N:24]([CH3:22])[CH2:25][C:26](=[O:27])[N:56]4[CH2:51][CH2:52][CH2:53][CH2:54][CH2:55]4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:39])=[CH:40][CH:41]=1参加物
10
反応物 7
HCID 6328Methyl iodide
HCID 99734-Fluorobenzoic Acid
HCID 11430Potassium Carbonate2 回
HCID 81531Diisopropylethylamine
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 112653092-Iodo-1-morpholin-4-yl-ethanone
HCID 227369774-Methoxy-1,3-benzothiazole-2,7-diamine生成物 1
試薬・触媒・溶媒 2
実験手順
From 4-methoxy-benzothiazole-2,7-diamine with potassium carbonate and 2-iodo-1-morpholin-4-yl-ethanone in DMF, then treatment with potassium carbonate and iodomethane in DMF, then treatment with 4-fluorobenzoic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 457 (M+H+, 100).
出典と根拠
- ORDレコード
- ord-7441783e4fed4d589eb82a201d1bfcf7
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06713499B2
関連ノート
読み込み中…