Benzyl Bromide → HCID 86690094、化合物
反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[O:9]=[C:10]1[CH2:19][C:12]2([CH2:15][CH:14]([C:16]([OH:18])=[O:17])[CH2:13]2)[CH2:11]1.CCN(C(C)C)C(C)C>C(Cl)(Cl)Cl.C(#N)C>[O:9]=[C:10]1[CH2:11][C:12]2([CH2:15][CH:14]([C:16]([O:18][CH2:2][C:3]3[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=3)=[O:17])[CH2:13]2)[CH2:19]1参加物
6
実験手順
A solution of (bromomethyl)benzene (564 mg) in CHCl3 (1 mL) was added to a stirred solution of 6-oxospiro[3.3]heptane-2-carboxylic acid (462 mg) and DIPEA (0.576 mL) in acetonitrile (2 mL) and CHCl3 (2 mL) and the mixture was stirred at rt overnight. The reaction mixture was evaporated to dryness and then purified by silica gel FCC (1:1 DCM:hexanes) to afford benzyl 6-oxospiro[3.3]heptane-2-carboxylate as a clear oil.
後処理
- customThe reaction mixture was evaporated to dryness
- custompurified by silica gel FCC (1:1 DCM:hexanes)
出典と根拠
- ORDレコード
- ord-6ba32ce6867541d787fcc22a433c322f
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09326973B2
反応ノート
読み込み中…