Boron trifluoride etherate → HCID 86690118、化合物

To a solution of Deoxo-Fluor® (1.5 mL, 8.14 mmol) in DCM (5 mL) was added boron trifluoride etherate (1 mL, 7.89 mmol) dropwise at 0° C. The mixture was stirred at rt for 1 h. A solution of (R)-(2-methyl-4-oxotetrahydro-2H-pyran-2-yl)methyl benzoate (0.7 g, 2.82 mmol) in DCM (5 mL) and triethylamine trihydrofluoride (0.1 mL, 0.614 mmol) were added dropwise in a 0° C. The reaction mixture was stirred at rt for 18 h and was recooled the reaction mixture in ice bath, added another portion of Deoxo-Fluor® (1 mL, 5.42 mmol) dropwise. The reaction mixture was stirred at rt for another 2 h. The reaction mixture was cautionly poured into a stirred ice cold aq. NaHCO3 solution and extracted with EtOAc (2×). The combined organic extraction was washed with NaHCO3, brine, dried (MgSO4), removed the solvent and purified on a 25 g silica gel cartridge (EtOAc/hex: 0 to 20%) to afford the product contaminated with vinyl by-product. The product was dissolved in acetone (4 mL), THF (16 mL), and added water (4 mL), NMO (0.330 g, 2.82 mmol) and osmium tetroxide (0.4 mL, 0.032 mmol) in ice bath. The reaction mixture was stirred at rt for 3 days and was diluted with EtOAc, washed with water, NH4Cl, brine, dried (MgSO4) and purified by silica gel flash chromatography to afford (R)-(4,4-difluoro-2-methyltetrahydro-2H-pyran-2-yl)methyl benzoate (0.48 g, 63%). 1H NMR (400 MHz, CHLOROFORM-d) ppm 8.13-8.04 (m, 2H), 7.60 (tt, J=7.4, 1.3 Hz, 1H), 7.52-7.39 (m, 2H), 4.42-4.34 (m, 1H), 4.24 (d, J=11.5 Hz, 1H), 4.00-3.84 (m, 2H), 2.21-1.93 (m, 4H), 1.46-1.36 (m, 3H).

1. stirringThe reaction mixture was stirred at rt for 18 h
2. stirringThe reaction mixture was stirred at rt for another 2 h
3. extractionextracted with EtOAc (2×)
4. extractionThe combined organic extraction
5. washwas washed with NaHCO3, brine
6. dry with materialdried (MgSO4)
7. customremoved the solvent
8. custompurified on a 25 g silica gel cartridge (EtOAc/hex: 0 to 20%)
9. customto afford the product
10. stirringThe reaction mixture was stirred at rt for 3 days
11. washwashed with water, NH4Cl, brine
12. dry with materialdried (MgSO4)
13. custompurified by silica gel flash chromatography

ORDレコード

ord-a76199326f17496c8cc261103d024d4b

出典データセット

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09326973B2