2-(2Indenyl)indole → 6-Oxo carbazole
反応式
C1[C:9]2[C:4](=CC=CC=2)[CH:3]=[C:2]1[C:10]1[NH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][CH:15]=[CH:14][CH:13]=2.C(/C=C\C(OCC)=[O:24])#N>Cl[Sn](Cl)(Cl)Cl.[Al+3].[Cl-].[Cl-].[Cl-].C([Al](Cl)Cl)C.[Al](Cl)(CC)CC.C(O)(C(F)(F)F)=O.C(Cl)Cl.C1(C)C=CC=CC=1>[O:24]=[C:4]1[CH:3]=[CH:2][C:10]2[C:18]([C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=2)=[CH:9]1参加物
10
実験手順
In Method B (FIG. 2), a 2-(heteroaryl)indole derivative (1-3), or 2-(aryl)indole derivative such as 2-(2-indenyl)indole 4 is reacted with ethyl cis-β-cyanoacrylate in the presence of a catalyst such as SnCl4, AlCl3, EtAlCl2, Et2AlCl or TFA in CH2Cl2, C2H4Cl2 or toluene as solvent to give the 6-oxo carbazole compounds of formula I of the invention.
出典と根拠
- ORDレコード
- ord-7186f49c7b7e4d1fbb08b8b3540eddf4
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05616724
反応ノート
読み込み中…
