反応式
[Br:1][C:2]1[C:3]([Cl:9])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[Br:10]N1C(=O)CCC1=O.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[Br:1][C:2]1[C:3]([Cl:9])=[N:4][C:5]([CH2:8][Br:10])=[CH:6][CH:7]=1参加物
5
反応条件
- 温度
- 90 °C
実験手順
In 21 mL of carbon tetrachloride, 3-bromo-2-chloro-6-methylpyridine (880 mg, 4.26 mmol) was dissolved, and N-bromosuccinimide (682 mg, 3.83 mmol) and AIBN (70 mg, 0.426 mmol) were added, followed by stirring at 90° C. for one hour. The resulting reaction solution was concentrated, and the residue thus obtained was purified by silica gel column chromatography (chloroform/methanol=100/0 to 95/5), whereby 3-bromo-6-(bromomethyl)-2-chloropyridine was obtained as a crude purified product.
後処理
- customThe resulting reaction solution
- concentrationwas concentrated
- customthe residue thus obtained
- customwas purified by silica gel column chromatography (chloroform/methanol=100/0 to 95/5)
出典と根拠
- ORDレコード
- ord-753727f860cb43a9b55d455bf339e35d
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09346787B2
関連ノート
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