Triphosgene → HCID 86717347、化合物

反応式

[NH2:1][C:2]1([C:13]2[CH:18]=[CH:17][C:16]([CH:19]([CH3:21])[CH3:20])=[CH:15][C:14]=2[O:22][CH3:23])[C:10](=[O:11])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:12].Cl[C:25](Cl)([O:27]C(=O)OC(Cl)(Cl)Cl)Cl.Cl.[CH3:37][O:38][NH2:39]>C1COCC1>[CH:19]([C:16]1[CH:17]=[CH:18][C:13]([C:2]2([NH:1][C:25]([NH:39][O:38][CH3:37])=[O:27])[C:10](=[O:11])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:12])=[C:14]([O:22][CH3:23])[CH:15]=1)([CH3:21])[CH3:20]

参加物

実験手順

A solution of 2-amino-2-(4-isopropyl-2-methoxyphenyl)-2H-inden-1,3-dione (0.50 g, 1.61 mmol) in anhydrous THF (20 ml) was added triphosgene (0.528 g, 1.77 mmol) and stirred for 15 min. The reaction mixture was concentrated and was dissolved in anhydrous THF (20 ml) and was added O-methyl-hydroxylamine hydrochloride (0.28 g, 4.04 mmol) was stirred for 2 hrs at room temperature. The reaction mixture was oncentrated and was purified using silica gel column chromatography (1:1=ethylacetate:hexane) to afford the title compound (420 mg, 69%).