Water → HCID 90323117、化合物

HRID 527198ノート

反応式

HRID 527198 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)[NH2:5].N1C=CC=CC=1.Cl[C:30]([O:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[O:31].O>C(#N)C>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:30](=[O:31])[O:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)[CH2:11][CH2:10]1

参加物

6

反応物 4

HCID 962WaterHCID 1049PyridineHCID 15891Phenyl chloroformateHCID 176097133-Fluoro-4-(4-(4-methoxyphenyl)piperazin-1-yl)aniline

生成物 1

HCID 90323117HCID 90323117、化合物収率 83%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 4 (0.32 g, 1 mmol) and pyridine (0.12 mL, 1.5 mmol) in acetonitrile (4 mL, 0.25M), phenyl chloroformate (0.16 mL, 1.2 mmol) was added at 0° C. and the reaction mixture was stirred at room temperature for overnight. Then water was added and the mixture was stirred for 30 min. The precipitated white solid was filtered and the solid was washed with acetonitrile and then dried under vacuum to obtain compound 5 (0.35 g, 83%).

後処理

  1. stirringthe mixture was stirred for 30 min
  2. filtrationThe precipitated white solid was filtered
  3. washthe solid was washed with acetonitrile
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-29b926f63f0c4de9b259f4ef280dc876
出典データセット
uspto-grants-2016_05
特許番号
US09346791B2

反応ノート

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