Diisopropylethylamine → HCID 178485620、化合物

HRID 527915

反応式

HRID 527915 の反応式
[CH3:1][NH:2][C@@H:3]1[CH2:7][CH2:6][N:5]([C:8]2[C:9]3[CH:16]=[CH:15][N:14]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[C:10]=3[N:11]=[CH:12][N:13]=2)[CH2:4]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C.[NH:56]1[CH:60]=[C:59]([CH2:61][C:62]([OH:64])=O)[N:58]=[CH:57]1>C1COCC1>[NH:56]1[CH:60]=[C:59]([CH2:61][C:62]([N:2]([CH3:1])[C@@H:3]2[CH2:7][CH2:6][N:5]([C:8]3[C:9]4[CH:16]=[CH:15][N:14]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[C:10]=4[N:11]=[CH:12][N:13]=3)[CH2:4]2)=[O:64])[N:58]=[CH:57]1

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 96215Imidazole-4-acetic acidHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 66765875(R)-N-methyl-1-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine

生成物 1

HCID 178485620HCID 178485620、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (R)—N-methyl-1-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine (0.29 mmol), TBTU (0.35 mmol) and DIPEA (0.58 mmol) in THF was slowly added 2-(1H-imidazol-4-yl)acetic acid (0.29 mmol). The mixture was stirred at room temperature overnight, then concentrated, diluted with water, and extracted with EtOAc. The combined extracts were dried, filtered and concentrated. The residue was purified by flash chromatography to give the title compound.

後処理

  1. concentrationconcentrated
  2. additiondiluted with water
  3. extractionextracted with EtOAc
  4. customThe combined extracts were dried
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe residue was purified by flash chromatography

出典と根拠

ORDレコード
ord-2d213c21ff16469e87bc93c1891701c0
出典データセット
uspto-grants-2016_05
特許番号
US09346810B2

関連ノート

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