Hydrochloric Acid → 4-(2-(2-Fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

HRID 532293

反応式

HRID 532293 の反応式
C[O:2][C:3]([C:5]1[S:25][C:8]2[N:9]=[CH:10][N:11]=[C:12]([NH:13][C:14]3[C:15]([O:20][CH2:21][CH:22]([F:24])[CH3:23])=[N:16][CH:17]=[CH:18][CH:19]=3)[C:7]=2[C:6]=1[CH3:26])=[O:4].[OH-].[Li+].Cl>C1COCC1>[F:24][CH:22]([CH3:23])[CH2:21][O:20][C:15]1[C:14]([NH:13][C:12]2[C:7]3[C:6]([CH3:26])=[C:5]([C:3]([OH:4])=[O:2])[S:25][C:8]=3[N:9]=[CH:10][N:11]=2)=[CH:19][CH:18]=[CH:17][N:16]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 58413371Methyl-4-(2-(2-fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate

生成物 1

HCID 584132524-(2-(2-Fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of methyl-4-(2-(2-fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (333 mg) in THF (10 ml) was added lithium hydroxide (1M; 8 ml) and the reaction stirred at room temperature overnight. The mixture was neutralized with HCl (1M; 8 ml) and concentrated in vacuo. The crude product was purified by chromatography.

後処理

  1. concentrationconcentrated in vacuo
  2. customThe crude product was purified by chromatography

出典と根拠

ORDレコード
ord-cf4abd6e932e4f58a73f36371919bc75
出典データセット
uspto-grants-2014_10
特許番号
US08853193B2

関連ノート

読み込み中…