Sodium Hydroxide → 5-(4-Aminophenyl)pyrazin-2(1H)-one

HRID 542459

反応式

HRID 542459 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][C:13](=[O:16])[NH:14][CH:15]=2)=[CH:6][CH:5]=1)([O-])=O.[OH-].[Na+].O.NN>[Pd].O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:11]=[CH:12][C:13](=[O:16])[NH:14][CH:15]=2)=[CH:8][CH:9]=1

参加物

6

反応物 3

HCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 138535735-(4-Nitrophenyl)pyrazin-2(1H)-one

生成物 1

HCID 123580285-(4-Aminophenyl)pyrazin-2(1H)-one収率 81.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

5-(4-Nitrophenyl)-2(1H)-pyrazinone (0.1 g) was warmed with water (2.5 ml) and 1N sodium hydroxide solution (0.46 ml) to about 70° C. To this solution was added 10% Palladium on charcoal (0.01 g), and subsequently hydrazine hydrate (0.1 ml). The well-stirred mixture was heated for 2 minutes, stirred for a further 2 minutes and filtered whilst hot. The filtrate was taken to pH6 with dilute hydrochloric acid, whereupon the solid was collected by filtration, washed with water and dried to give 5-(4-aminophenyl)-2(1H)-pyrazinone (0.07 g).

後処理

  1. temperatureThe well-stirred mixture was heated for 2 minutes
  2. filtrationfiltered whilst hot
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-b3e6d0bfa3eb4ffc9b418ef8e88ae029
出典データセット
uspto-grants-1987_04
特許番号
US04657906

関連ノート

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