Thionyl Chloride → (6-Chloro(3-pyridyl)methyl] (2-chloroethylamino}ethanenitrile

HRID 549223ノート

反応式

HRID 549223 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:12][CH2:13][CH2:14]O)[C:10]#[N:11])=[CH:4][CH:3]=1.S(Cl)([Cl:18])=O>N1C=CC=CC=1.C(Cl)(Cl)Cl>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH:9]([NH:12][CH2:13][CH2:14][Cl:18])[C:10]#[N:11])=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 86624867(6-Chloro(3-pyridyl)methyl](2-hydroxyethylamino}ethanenitrile

生成物 1

HCID 86624866(6-Chloro(3-pyridyl)methyl] (2-chloroethylamino}ethanenitrile

試薬・触媒・溶媒 2

HCID 1049Pyridine触媒HCID 6212Chloroform溶媒

実験手順

This compound was prepared in a manner analogous to that set forth in Step C of Example 1, using 5.7 grams (0.0255 mole) of 2-{[(6-chloro(3-pyridyl)methyl](2-hydroxyethylamino}ethanenitrile 3.2 grams (0.0268 mole) of thionyl chloride and one drop (catalyst) of pyridine in 50 mL of chloroform. The yield of the subject compound was 6.0 grams. The NMR spectrum was consistent with the proposed structure.

後処理

  1. customThis compound was prepared in a manner analogous to that set forth in Step C of Example 1

出典と根拠

ORDレコード
ord-58378f85ee644cb2850e5714cffc67a6
出典データセット
uspto-grants-2011_05
特許番号
US07943642B2

反応ノート

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