Pyrrolidine → 5-Benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

HRID 5514

反応式

HRID 5514 の反応式
[CH2:1]([O:8][C:9]1[C:10](=[O:17])[CH2:11][C:12]([CH:15]=[CH2:16])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1>O1CCCC1.C(OC(C)C)(C)C>[CH2:1]([O:8][C:9]1[C:10](=[O:17])[CH2:11][C:12]([CH2:15][CH2:16][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 31268PyrrolidineHCID 677480895-Benzyloxy-2-vinyl-4-pyridone

生成物 1

HCID 677480915-Benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone

試薬・触媒・溶媒 2

HCID 7914Diisopropyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (2.90 g) and pyrrolidine (5.33 ml) was heated and refluxed for an hour. The mixture was cooled and diluted with tetrahydrofuran (20 ml) and diisopropyl ether (80 ml). After being stirred for an hour at ambient temperature, the resulting precipitate was collected by filtration, washed with diisopropyl ether and air-dried at ambient temperature to give 5-benzyloxy-2-[2-(1-pyrrolidinyl)ethyl]4-pyridone (3.79 g).

後処理

  1. temperaturewas heated
  2. temperaturerefluxed for an hour
  3. temperatureThe mixture was cooled
  4. filtrationthe resulting precipitate was collected by filtration
  5. washwashed with diisopropyl ether
  6. customair-dried at ambient temperature

出典と根拠

ORDレコード
ord-03e7daa11f954f73ad1160c376faaee0
出典データセット
uspto-grants-1993_09
特許番号
US05244890

関連ノート

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