Ethyl chloroacetate → Ethyl sulfoacetate

HRID 553462

反応式

HRID 553462 の反応式
[O-:1][S:2]([O-:4])=[O:3].[Na+].[Na+].Cl[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>O.CCO>[CH2:12]([O:11][C:9]([CH2:8][S:2]([OH:4])(=[O:1])=[O:3])=[O:10])[CH3:13]

参加物

5

反応物 2

HCID 7751Ethyl chloroacetateHCID 24437Sodium Sulfite

生成物 1

HCID 12216623Ethyl sulfoacetate収率 100.1%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

To a solution of Na2SO3 (10 g, 79 mmol.) in 50 mL of H2O was added a solution of ethyl 2-chloroacetate (12.7 mL, 119 mmol.) in 55 mL of EtOH. The mixture was heated at reflux for 6 h, after which time all the volatiles were removed by evaporation under reduced pressure. The concentrated materials were dried to afford crude (ethoxycarbonyl)methanesulfonic acid (13.3 g, 100%) used directly without purification.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 6 h
  3. customafter which time all the volatiles were removed by evaporation under reduced pressure
  4. customThe concentrated materials were dried

出典と根拠

ORDレコード
ord-c88b6db0b6db47158d18750b41bcb397
出典データセット
uspto-grants-2011_11
特許番号
US08048862B2

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