1-Dodecanethiol → 1,3-Bis(dodecylsulfanyl)propan-2-ol

HRID 567186ノート

反応式

HRID 567186 の反応式
[CH2:1]([SH:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[Na].[CH2:15]([CH:17]1[O:19][CH2:18]1)Br>C(O)C.CCOCC>[CH2:1]([S:13][CH2:15][CH:17]([OH:19])[CH2:18][S:13][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

参加物

6

反応物 3

HCID 81951-DodecanethiolHCID 18430EpibromohydrinHCID 5360545Sodium

生成物 1

HCID 158395031,3-Bis(dodecylsulfanyl)propan-2-ol

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 3283Diethyl Ether溶媒

実験手順

26.6 ml Dodecanethiol was added to an ethylate solution of 2.6 g sodium in 100 ml ethanol and the solution was stirred for 1 hour at room temperature. Then 8.5 ml epibromohydrin was added dropwise within 30 min and stirred overnight. The residue was taken up in ether after removing the solvent, washed twice with water and dried. The desired compound crystallized on evaporation of the solution. Yield 28.5 g (62%).

後処理

  1. stirringstirred overnight
  2. customafter removing the solvent
  3. washwashed twice with water
  4. customdried
  5. customThe desired compound crystallized on evaporation of the solution

出典と根拠

ORDレコード
ord-9056b7813aa146589d3b2174d64054f7
出典データセット
uspto-grants-2001_01
特許番号
US06177469B1

反応ノート

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