Acetonitrile → 2-Thenoylacetonitrile

HRID 568589

反応式

HRID 568589 の反応式
C(O[C:4]([C:6]1[S:7][CH:8]=[CH:9][CH:10]=1)=[O:5])C.[H-].[Na+].[C:13](#[N:15])[CH3:14]>C1(C)C=CC=CC=1>[S:7]1[CH:8]=[CH:9][CH:10]=[C:6]1[C:4]([CH2:14][C:13]#[N:15])=[O:5]

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 24758Sodium hydrideHCID 76052Ethyl 2-thenoate

生成物 1

HCID 1418532-Thenoylacetonitrile収率 92.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

78.1 grams (0.5 mole) of thiophene-2-carboxylic acid ethyl ester and 30 grams (1 mole) of sodium hydride (80% suspension in white oil) were reacted with 41.5 grams (1 mole) of acetonitrile in 500 ml of dry toluene. There were obtained 70.0 grams (92.6% of theory) of 2-thiophenoylacetonitrile having a melting point of 110° C.

出典と根拠

ORDレコード
ord-6134339ac3da40398099f92e3039b85c
出典データセット
uspto-grants-1988_03
特許番号
US04728743

関連ノート

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