Water → 2-(4-(3-(4-Chlorophenyl)-1,2,4-thiadiazol-5-yl)piperazin-1-yl)-1-(4-methoxyphenyl)ethanol

A mixture of 2-(4-(3-(4-chlorophenyl)-1,2,4-thiadiazol-5-yl)piperazin-1-yl)-1-(4-methoxyphenyl)ethanone (75 mg, 175 μmol) and NaBH4 (10 mg, 264 μmol) in THF (5 mL) and MeOH (1 mL) was stirred at RT. Water (5 mL) and 10% aq.Na2CO3 (5 mL) was added and stirred for 10 min. The mixture was extracted with EtOAc; the organic layers were washed with brine (20 mL), dried over Na2SO4, filtered off and concentrated in vacuo.

1. stirringstirred for 10 min
2. extractionThe mixture was extracted with EtOAc
3. washthe organic layers were washed with brine (20 mL)
4. dry with materialdried over Na2SO4
5. filtrationfiltered off
6. concentrationconcentrated in vacuo

ORDレコード

ord-4a24e6a5f7bc4b4ab98474d66d43c2b1

出典データセット

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09023852B2